Protein Moonlighting Revealed by Noncatalytic Phenotypes of Yeast Enzymes
نویسندگان
چکیده
منابع مشابه
Isozymes, moonlighting proteins and promiscous enzymes
The structures of isoenzymes differ and yet these catalyse the same type of reaction. These structures evolved to suit the physiological needs and are located in different parts of cells or tissues. Moonlighting proteins represent the same structure performing very different biological functions. Biological promiscuity reveals that the same active sites can catalyse different types of reactions...
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We recently presented the first computational method for the large-scale identification of what we have termed " extreme multifunctional proteins " (EMF) [1]. These are proteins whose multiple functions are very dissimilar to one another. While obviously related to moonlighting proteins, we chose to coin a new term because we felt that the current definition of moonlighting is too constrictive....
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Reductive evolution during the adaptation to obligate parasitism and expansions of gene families encoding virulence factors are characteristics evident to greater or lesser degrees in all parasitic protists studied to date. Large evolutionary distances separate many parasitic protists from the yeast and animal models upon which classic views of eukaryotic biochemistry are often based. Thus a co...
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ژورنال
عنوان ژورنال: Genetics
سال: 2018
ISSN: 1943-2631
DOI: 10.1534/genetics.117.300377